How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow?
What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names Other names. Other uses for this medicine. What special precautions should I follow? Before taking leucovorin, tell your doctor and pharmacist if you are allergic to leucovorin, levoleucovorin, folic acid Folicet, in multivitamins , any other medications, or any of the ingredients in leucovorin tablets. Ask your pharmacist for a list of the ingredients.
Be sure to mention any of the following: certain medications for seizures such as phenobarbital, phenytoin Dilantin , and primidone Mysoline ; and trimethoprim-sulfamethoxazole Bactrim, Septra. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor will not prescribe leucovorin to treat this type of anemia. Also tell your doctor if you are nauseated. If you become pregnant while taking leucovorin, call your doctor.
Unless your doctor tells you otherwise, continue your normal diet. Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately: diarrhea rash hives itching difficulty breathing or swallowing Leucovorin may cause other side effects.
Methods: We conducted a multicenter randomized, double-blind, placebo-controlled trial of leucovorin administration, 2. Every 3 weeks for 52 weeks, patients were evaluated for rheumatic disease activity and side effects. Dosage adjustments for both methotrexate and leucovorin were made as needed, according to a defined protocol. Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:. You will be checked regularly by your health care professional while you are taking Leucovorin, to monitor side effects and check your response to therapy.
Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate.
Leucovorin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anti-cancer effects with fluorouracil or to help prevent or lessen side effects with methotrexate. Fluorouracil when given alone stays in the body for only a short time.
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