There is no significant clinical literature on the effects of mephedrone and the other cathinone derivatives currently gaining popularity on the drug scene, so we have to rely on anecdotal reports from users. Many people who have used mephedrone and similar drugs report that their experiences are similar to taking amphetamines, ecstasy or cocaine, producing a sense of euphoria and wellbeing, with users becoming more alert, confident and talkative.
People who have used methylone, which is closely chemically related to ecstasy, particularly report a feeling of empathy with those around them. People who snort these substances can experience extremely sore nasal passages, throats and mouths, with burns or cuts caused by the chemicals sometimes leading to nose bleeds. Some people to choose to swallow the drugs instead to avoid these particular problems.
Like other stimulant drugs, the cathinone derivatives can have an impact on the heart. Mr Shapiro said: "The harms and potential danger with taking drugs such as amphetamines and cocaine are well known, and these substances are related to those drugs.
The real risk comes with mixing different drugs, and if you drink alcohol on top of this it can become a truly toxic mix. Mephedrone ban 'took too long'. What is mephedrone? Baumann and colleagues note that much research has shown that drugs which increase extracellular dopamine—as do all the drugs they tested—have high potential for addiction.
However, they emphasize that this hypothesis needs to be tested. Baumann, M. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 37 5 —, Full Text.
PDF documents require the free Adobe Reader. Skip to main content. Search form. Archive Home. Article PubMed Google Scholar. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine MDMA -induced serotonin neurotoxicity and core body temperature in the rat.
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Reprints and Permissions. Baumann, M. Neuropsychopharmacol 37, — Download citation. Received : 30 August Revised : 28 October Accepted : 29 October Published : 14 December Issue Date : April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
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Skip to main content Thank you for visiting nature. Download PDF. Figure 1. Chemical structures of designer methcathinone analogs and related compounds. Full size image. In Vitro Transporter Assays In our initial investigations, we tested the ability of mephedrone, methylone, MDMA, and methamphetamine to evoke the release of radiolabeled substrates in rat brain synaptosomes using modifications of published methods Rothman et al, In Vivo Microdialysis Experiments In vivo microdialysis sampling was carried out as described, with minor modifications Baumann et al, Figure 2.
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